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Article

Decreased BRCA1 confers tamoxifen resistance in breast cancer cells by altering estrogen receptor-coregulator interactions.

Oncogene - 29 Jan 2009

Wen J, Li R, Lu Y, Shupnik M A

Abstract excerpt

The breast cancer susceptibility gene 1 (BRCA1) is mutated in approximately 50% of hereditary breast cancers, and its expression is decreased in 30-40% of sporadic breast cancers, suggesting a general role in breast cancer development. BRCA1 physically and functionally interacts with estrogen receptor-alpha (ERalpha) and several transcriptional regulators. We investigated the relationship between cellular BRCA1...

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Share to Antineoplastic Agents, Hormonal
Share to BRCA1 Protein
Share to Cyclin D1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Estrogen Receptor alpha

Share to Gene Expression Regulation, Neoplastic

Share to RNA, Small Interfering

Share to Tamoxifen

Source

Open in PubMed Open full text

Identifiers

PMID: 18997820
DOI: 10.1038/onc.2008.405
PMCID: PMC2714665

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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