Epigenetic changes in BRCA1-mutated familial breast cancer.

doi:10.1016/j.cancergen.2015.02.001

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Article

Epigenetic changes in BRCA1-mutated familial breast cancer.

Cancer genetics - 1 May 2015

Downs Bradley, Wang San Ming

Abstract excerpt

Familial breast cancer occurs in about 10% of breast cancer cases. Germline mutation in BRCA1 is the most penetrant predisposition for the disease. Mutated BRCA1 leads to disease by causing genome instability via multiple mechanisms including epigenetic changes. This review summarizes recent progress in studying the correlation between BRCA1 predisposition and epigenetic alterations in BRCA1-type familial breast...

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Identifiers

PMID: 25800897
DOI: 10.1016/j.cancergen.2015.02.001
PMCID: PMC4466075

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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