Article
BRCA1 at the crossroad of multiple cellular pathways: approaches for therapeutic interventions.
Molecular cancer therapeutics - 1 Jun 2006
Yarden Ronit I, Papa Moshe Z
Abstract excerpt
Approximately 10% of the cases of breast cancer and invasive ovarian cancer are hereditary, occurring predominantly in women with germ-line mutations in the BRCA1 or BRCA2 genes. Low expression of these genes in sporadic tumors extends their significance to sporadic breast and ovarian cancers as well. For over a decade since its identification, extensive research has been directed toward understanding the...
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