Article
A role of estrogen/ERalpha signaling in BRCA1-associated tissue-specific tumor formation.
Oncogene - 8 Nov 2007
Li W, Xiao C, Vonderhaar B K, Deng C-X
Abstract excerpt
Estrogen and its receptor alpha (ERalpha) have been implicated in the tissue-specific tumorigenesis associated with BRCA1 mutations. However, the majority of breast cancers developed in human BRCA1 mutation carriers are ERalpha-negative, challenging the link between BRCA1 and estrogen/ERalpha in breast cancer formation. Using a mouse model lacking the full-length form of BRCA1, here we show that ERalpha is highly...
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