Article
Restricted expression of Mov13 mutant alpha 1(I) collagen gene in osteoblasts and its consequences for bone development.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Dec 1993
Kratochwil K, Ghaffari-Tabrizi N, Holzinger I, Harbers K
Abstract excerpt
Cell type-specific differences in the transcriptional control of the mouse gene coding for the alpha 1 chain of collagen type I (Col1a1) have been revealed previously with the help of the Mov13 mouse strain which carries a retroviral insert in the first intron of the gene. Transcription of this mutant Col1a1 allele is completely blocked in all mesodermal cell types tested so far, with the exception of the...
Topics
- Alleles
- Animals
- Bone Development
- Bone and Bones
- Collagen
- Gene Expression
- Mice
- Mice, Inbred C57BL
- Mutagenesis, Insertional
- Mutation
- Osteoblasts