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Article

Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990

Wu H, Byrne M H, Stacey A, Goldring M B, Birkhead J R, Jaenisch R, Krane S M

Abstract excerpt

Collagenase (matrix metalloproteinase 1) cleaves type I, II, and III collagen helices at a specific site between Gly-Ile or Gly-Leu bonds (residues 775 and 776, P1-P1'). To understand the mechanism of collagen processing, mutations around the cleavage site have been introduced into the cloned murine pro alpha 1(I) collagen (Col1a1) gene. These mutant constructs have been transfected into homozygous Mov13...

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Identifiers

PMID: 2165607
DOI: 10.1073/pnas.87.15.5888
PMCID: PMC54434

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene.PMID 2165607Read ↗

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