Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Embryonic lethal mutation in mice induced by retrovirus insertion into the alpha 1(I) collagen gene.

Nature - 1 Jan 2000

Schnieke A, Harbers K, Jaenisch R

Abstract excerpt

Experimental insertion of a retrovirus into the germ line of mice has resulted in an embryonic recessive lethal mutation. Integration of the proviral genome occurred at the 5' end of the alpha 1(I) collagen gene, leading to complete transcriptional block. Developmental arrest of embryos homozygou...

Topics

Animals
Chromosome Mapping
Collagen
Female
Gene Expression Regulation
Genes, Lethal
Mice
Mice, Inbred C57BL
Mutation
Pregnancy
Retroviridae
Retroviridae Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 6308457
DOI: 10.1038/304315a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-6308457-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Embryonic lethal mutation in mice induced by retrovirus insertion into the alpha 1(I) collagen gene.PMID 6308457Read ↗

Retroviruses as genetic tools to isolate transcriptionally active chromosomal regions.Semantic proximity Read ↗

A large-scale gene-trap screen for insertional mutations in developmentally regulated genes in mice.Semantic proximity Read ↗

Retrovirus-induced insertional mutagenesis: mechanism of collagen mutation in Mov13 mice.Semantic proximity Read ↗

Retrovirus-induced de novo methylation of flanking host sequences correlates with gene inactivity.Semantic proximity Read ↗

Gene insertion: current progress and long-term goals.Semantic proximity Read ↗

Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice.Semantic proximity Read ↗

Mice with a targeted intronic deletion in the Col1a1 gene respond to bleomycin-induced pulmonary fibrosis with increased expression of the mutant allele.Semantic proximity Read ↗

Gene trap integrations expressed in the developing heart: insertion site affects splicing of the PT1-ATG vector.Semantic proximity Read ↗

Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion.Semantic proximity Read ↗

Partial rescue of a lethal phenotype of fragile bones in transgenic mice with a chimeric antisense gene directed against a mutated collagen gene.Semantic proximity Read ↗

Fv1, the mouse retrovirus resistance gene.Semantic proximity Read ↗

Tissue- and development-specific expression in transgenic mice of a type I procollagen (COL1A1) minigene construct with 2.3 kb of the promoter region and 2 kb of the 3'-flanking region. Specificity is independent of the putative regulatory sequences in the first intron.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.