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Article

Embryonic lethal mutation in mice induced by retrovirus insertion into the alpha 1(I) collagen gene.

Nature - 1 Jan 2000

Schnieke A, Harbers K, Jaenisch R

Abstract excerpt

Experimental insertion of a retrovirus into the germ line of mice has resulted in an embryonic recessive lethal mutation. Integration of the proviral genome occurred at the 5' end of the alpha 1(I) collagen gene, leading to complete transcriptional block. Developmental arrest of embryos homozygous at the mutated allele coincides with high expression of the gene in normal embryogenesis. Insertion mutagenesis by...

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PMID: 6308457
DOI: 10.1038/304315a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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