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Article

Partial rescue of a lethal phenotype of fragile bones in transgenic mice with a chimeric antisense gene directed against a mutated collagen gene.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 1994

Khillan J S, Li S W, Prockop D J

Abstract excerpt

Previously, transgenic mice were prepared that developed a lethal phenotype of fragile bones because they expressed an internally deleted mini-gene for the pro alpha 1(I) chain of human type I procollagen. The shortened pro alpha 1(I) chains synthesized from the human transgene bound to and produced degradation of normal pro alpha 1(I) chains synthesized from the normal mouse alleles. Here we assembled an...

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Identifiers

PMID: 8022775
DOI: 10.1073/pnas.91.14.6298
PMCID: PMC44188

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Partial rescue of a lethal phenotype of fragile bones in transgenic mice with a chimeric antisense gene directed against a mutated collagen gene.PMID 8022775Read ↗

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Bone fragility in transgenic mice expressing a mutated gene for type I procollagen (COL1A1) parallels the age-dependent phenotype of human osteogenesis imperfecta.Semantic proximity Read ↗

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