Partial rescue of a lethal phenotype of fragile bones in transgenic mice with a chimeric antisense gene directed against a mutated collagen gene.

doi:10.1073/pnas.91.14.6298

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Article

Partial rescue of a lethal phenotype of fragile bones in transgenic mice with a chimeric antisense gene directed against a mutated collagen gene.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 1994

Khillan J S, Li S W, Prockop D J

Abstract excerpt

Previously, transgenic mice were prepared that developed a lethal phenotype of fragile bones because they expressed an internally deleted mini-gene for the pro alpha 1(I) chain of human type I procollagen. The shortened pro alpha 1(I) chains synthesized from the human transgene bound to and produ...

Topics

Animals
Base Sequence
Blotting, Western
Bone Diseases
Chimera
Collagen
DNA Primers
DNA, Antisense
Female
Genes, Lethal
Genes, Synthetic
Humans
Introns
Male
Mice
Mice, Transgenic
Molecular Sequence Data
Pedigree

Source

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Identifiers

PMID: 8022775
DOI: 10.1073/pnas.91.14.6298
PMCID: PMC44188

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8022775-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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