Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intron sequences determine the expression of kappa light chain genes.

Molecular immunology - 1 Feb 1994

Chou C L, Morrison S L

Abstract excerpt

Alterations in kappa light chain expression were demonstrated to originate from genomic changes in the L-V intron (L-IVS) which changed the splicing pattern of the kappa mRNA. In R15, a mutant of mouse myeloma W3129 which produces no kappa light chain, a 358 bp novel sequence element (R15ns) of unknown origin replaced 19 bases of wild-type L-IVS, both altering the normal splicing pattern and activating a cryptic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Blotting, Southern
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to RNA, Messenger

Source

Identifiers

PMID: 8309481
DOI: 10.1016/0161-5890(94)90082-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intron sequences determine the expression of kappa light chain genes.PMID 8309481Read ↗

An insertion-deletion event in murine immunoglobulin kappa gene resembles mutations at heavy-chain disease loci.Semantic proximity Read ↗

Chromatin Structural Analyses of the Mouse Igκ Gene Locus Reveal New Hypersensitive Sites Specifying a Transcriptional Silencer and EnhancerSemantic proximity Read ↗

The 3' Igkappa enhancer contains RNA polymerase II promoters: implications for endogenous and transgenic kappa gene expression.Semantic proximity Read ↗

Deletion of the immunoglobulin kappa chain intron enhancer abolishes kappa chain gene rearrangement in cis but not lambda chain gene rearrangement in trans.Semantic proximity Read ↗

Transcription, beta-like DNA polymerases and hypermutation.Semantic proximity Read ↗

Molecular mechanisms and selective influences that shape the kappa gene repertoire of IgM+ B cells.Semantic proximity Read ↗

Variegated transcriptional activation of the immunoglobulin kappa locus in pre-b cells contributes to the allelic exclusion of light-chain expression.Semantic proximity Read ↗

A targeted kappa immunoglobulin gene containing a deletion of the nuclear matrix association region exhibits spontaneous hyper-recombination in pre-B cells.Semantic proximity Read ↗

Novel recombinations of the IG kappa-locus that result in allelic exclusion.Semantic proximity Read ↗

Genomic organization of the gene encoding the p65 subunit of NF-kappa B: multiple variants of the p65 protein may be generated by alternative splicing.Semantic proximity Read ↗

Structure and expression of the human immunoglobulin lambda genes.Semantic proximity Read ↗

RNA surveillance down-regulates expression of nonfunctional kappa alleles and detects premature termination within the last kappa exon.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.