Article
Intron sequences determine the expression of kappa light chain genes.
Molecular immunology - 1 Feb 1994
Chou C L, Morrison S L
Abstract excerpt
Alterations in kappa light chain expression were demonstrated to originate from genomic changes in the L-V intron (L-IVS) which changed the splicing pattern of the kappa mRNA. In R15, a mutant of mouse myeloma W3129 which produces no kappa light chain, a 358 bp novel sequence element (R15ns) of u...
Topics
- Animals
- Antibody Diversity
- Base Sequence
- Blotting, Southern
- Cloning, Molecular
- DNA
- Gene Expression Regulation
- Immunoglobulin Variable Region
- Immunoglobulin kappa-Chains
- Introns
- Mice
- Molecular Sequence Data
- Mutation
- RNA Splicing
- RNA, Messenger
- Tumor Cells, Cultured