Mice with a targeted intronic deletion in the Col1a1 gene respond to bleomycin-induced pulmonary fibrosis with increased expression of the mutant allele.

Abstract excerpt

Experiments designed to examine the role of the first intron in regulation of the Col1a1 gene by transfection and in transgenic mice have led to conflicting conclusions. Recently, Hormuzdi et al. [Hormuzdi, S.G., Penttinen, R., Jaenisch, R., Bornstein, P., 1998. A gene-targeting approach identifies a function for the first intron in expression of the alpha1(I) collagen. Mol. Cell. Biol. 18, 3368-3375.] created a...

Topics

• Alleles
• Animals
• Bleomycin
• Collagen
• Female
• Gene Deletion
• Gene Expression Regulation
• Introns
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Mutant Strains
• Pulmonary Fibrosis