Article
Dimerization properties of mutant thyroid hormone beta-receptors with auxiliary proteins.
The Journal of endocrinology - 1 Sept 1997
Tagami T, Nakamura H, Sasaki S, Miyoshi Y, Nakao K
Abstract excerpt
Hormonal responsiveness in peripheral tissues is variable in patients with resistance to thyroid hormone (RTH). One cause of this may be differential interaction of RTH mutants of thyroid hormone receptor beta (TR beta) with TR auxiliary proteins (TRAPs). We used gel shift mobility assays to exam...
Topics
- Base Sequence
- Cell Line
- Cell Nucleus
- Dimerization
- Electrophoresis, Polyacrylamide Gel
- Humans
- Liver
- Molecular Sequence Data
- Mutation
- Proteins
- Receptors, Retinoic Acid
- Receptors, Thyroid Hormone
- Retinoid X Receptors
- Thyroid Hormone Resistance Syndrome
- Transcription Factors
