Article
Understanding the molecular mechanism of dominant negative action of mutant thyroid hormone beta 1-receptors: the important role of the wild-type/mutant receptor heterodimer.
Endocrinology - 1 Feb 1996
Zhu X G, Yu C L, McPhie P, Wong R, Cheng S Y
Abstract excerpt
The clinical manifestations of patients with resistance to thyroid hormone result from inhibition of the functions of wild-type thyroid hormone receptors (wTRs) by the dominant negative effect of mutant TR beta 1 receptors (mTR beta 1). One of the proposed mechanisms by which mTR beta 1 exerts it...
Topics
- Animals
- Base Sequence
- Binding Sites
- Genes, Dominant
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Promoter Regions, Genetic
- Rats
- Receptors, Thyroid Hormone
- Thyroid Hormones
- Triiodothyronine