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Article

Early gene responses to transforming growth factor-beta in cells lacking growth-suppressive RB function.

Molecular and cellular biology - 1 Oct 1991

Zentella A, Weis F M, Ralph D A, Laiho M, Massagué J

Abstract excerpt

The growth-suppressive function of the retinoblastoma susceptibility gene product, RB, has been implicated in the mediation of growth inhibition and negative regulation of certain proliferation related genes by transforming growth factor-beta 1 (TGF-beta 1). Early gene responses to TGF-beta 1 were examined in order to determine their dependence on the cell cycle and on the growth-suppressive function of RB....

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Identifiers

PMID: 1922028
DOI: 10.1128/mcb.11.10.4952-4958.1991
PMCID: PMC361474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Early gene responses to transforming growth factor-beta in cells lacking growth-suppressive RB function.PMID 1922028Read ↗

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Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein.Semantic proximity Read ↗

Repression of RNA polymerase III transcription by the retinoblastoma protein.Semantic proximity Read ↗

E2f binding-deficient Rb1 protein suppresses prostate tumor progression in vivo.Semantic proximity Read ↗

Temperature-sensitive mutation of DNA polymerase alpha induces growth-suppressive phenotypes involving retinoblastoma protein and cyclin D1.Semantic proximity Read ↗

Rescue of embryonic epithelium reveals that the homozygous deletion of the retinoblastoma gene confers growth factor independence and immortality but does not influence epithelial differentiation or tissue morphogenesis.Semantic proximity Read ↗

NF-kappa B-dependent induction of cyclin D1 by retinoblastoma protein (pRB) family proteins and tumor-derived pRB mutants.Semantic proximity Read ↗

RB reversibly inhibits DNA replication via two temporally distinct mechanisms.Semantic proximity Read ↗

An E2F dominant negative mutant blocks E1A induced cell cycle progression.Semantic proximity Read ↗

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