Article
Early gene responses to transforming growth factor-beta in cells lacking growth-suppressive RB function.
Molecular and cellular biology - 1 Oct 1991
Zentella A, Weis F M, Ralph D A, Laiho M, Massagué J
Abstract excerpt
The growth-suppressive function of the retinoblastoma susceptibility gene product, RB, has been implicated in the mediation of growth inhibition and negative regulation of certain proliferation related genes by transforming growth factor-beta 1 (TGF-beta 1). Early gene responses to TGF-beta 1 wer...
Topics
- Animals
- Blotting, Northern
- Cell Cycle
- Cell Line
- Down-Regulation
- Genes, Retinoblastoma
- Humans
- Kinetics
- Mink
- Mutation
- Oncogene Protein p65(gag-jun)
- Plasminogen Inactivators
- Proto-Oncogene Proteins c-myc
- Retinoblastoma Protein
- Transcription, Genetic
- Transforming Growth Factor beta
- Tumor Cells, Cultured