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Article

RB reversibly inhibits DNA replication via two temporally distinct mechanisms.

Molecular and cellular biology - 1 Jun 2004

Angus Steven P, Mayhew Christopher N, Solomon David A, Braden Wesley A, Markey Michael P, Okuno Yukiko, Cardoso M Cristina, Gilbert David M, Knudsen Erik S

Abstract excerpt

The retinoblastoma (RB) tumor suppressor is a critical negative regulator of cellular proliferation. Repression of E2F-dependent transcription has been implicated as the mechanism through which RB inhibits cell cycle progression. However, recent data have suggested that the direct interaction of RB with replication factors or sites of DNA synthesis may contribute to its ability to inhibit S phase. Here we show...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15169903
DOI: 10.1128/MCB.24.12.5404-5420.2004
PMCID: PMC419877

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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RB reversibly inhibits DNA replication via two temporally distinct mechanisms.PMID 15169903Read ↗

RB Loss Promotes Aberrant Ploidy by Deregulating Levels and Activity of DNA Replication FactorsSemantic proximity Read ↗

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Histone Deacetylation of RB-Responsive Promoters: Requisite for Specific Gene Repression but Dispensable for Cell Cycle InhibitionSemantic proximity Read ↗

RBP1 Recruits the mSIN3-Histone Deacetylase Complex to the Pocket of Retinoblastoma Tumor Suppressor Family Proteins Found in Limited Discrete Regions of the Nucleus at Growth ArrestSemantic proximity Read ↗

Retinoblastoma Tumor Suppressor Targets dNTP Metabolism to Regulate DNA ReplicationSemantic proximity Read ↗

Repression of RNA polymerase III transcription by the retinoblastoma protein.Semantic proximity Read ↗

Using kinetic studies to uncover new Rb functions in inhibiting cell cycle progression.Semantic proximity Read ↗

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