Article
E2f binding-deficient Rb1 protein suppresses prostate tumor progression in vivo.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jan 2011
Sun Huifang, Wang Yanqing, Chinnam Meenalakshmi, Zhang Xiaojing, Hayward Simon W, Foster Barbara A, Nikitin Alexander Y, Wills Marcia, Goodrich David W
Abstract excerpt
Mutational inactivation of the RB1 tumor suppressor gene initiates retinoblastoma and other human cancers. RB1 protein (pRb) restrains cell proliferation by binding E2f transcription factors and repressing the expression of cell cycle target genes. It is presumed that loss of pRb/E2f interaction accounts for tumor initiation, but this has not been directly tested. RB1 mutation is a late event in other human...
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