Article
Rescue of embryonic epithelium reveals that the homozygous deletion of the retinoblastoma gene confers growth factor independence and immortality but does not influence epithelial differentiation or tissue morphogenesis.
The Journal of biological chemistry - 15 Nov 2002
Day Kathleen C, McCabe Michael T, Zhao Xin, Wang Yuzhuo, Davis Joanne N, Phillips John, Von Geldern Marion, Ried Thomas, KuKuruga Mark A, Cunha Gerald R, Hayward Simon W, Day Mark L
Abstract excerpt
The ability to rescue viable prostate precursor tissue from retinoblastoma-deficient (Rb-/-) fetal mice has allowed for the isolation and characterization of the first Rb-/- prostate epithelial cell line. This cell line, designated Rb-/-PrE, was utilized for experiments examining the consequences of Rb loss on an epithelial population. These findings demonstrated that Rb deletion has no discernible effect on...
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