Article
Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2008
Barber Thomas D, McManus Kirk, Yuen Karen W Y, Reis Marcelo, Parmigiani Giovanni, Shen Dong, Barrett Irene, Nouhi Yasaman, Spencer Forrest, Markowitz Sanford, Velculescu Victor E, Kinzler Kenneth W, Vogelstein Bert, Lengauer Christoph, Hieter Philip
Abstract excerpt
Although the majority of colorectal cancers exhibit chromosome instability (CIN), only a few genes that might cause this phenotype have been identified and no general mechanism underlying their function has emerged. To systematically identify somatic mutations in potential CIN genes in colorectal...
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