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Mathematical algorithms for high-resolution DNA melting analysis.

Methods in enzymology - 1 Jan 2009

Palais Robert, Wittwer Carl T

Abstract excerpt

This chapter discusses mathematical and computational methods that enhance the modeling, optimization, and analysis of high-resolution DNA melting assays. In conjunction with recent improvements in reagents and hardware, these algorithms have enabled new closed-tube techniques for genotyping, mutation scanning, confirming or ruling out genotypic identity among living related organ donors, and quantifying...

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PMID: 19216933
DOI: 10.1016/S0076-6879(08)03813-5

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