Article
Enhanced primer selection and synthetic amplicon templates optimize high-resolution melting analysis of single-nucleotide polymorphisms in a large population.
Genetic testing and molecular biomarkers - 1 Sept 2013
Bruzzone Carol M, Tawadros Patrick S, Boardman Lisa A, Steer Clifford J
Abstract excerpt
AIMS: High-resolution melting (HRM) screening and scanning for single-nucleotide polymorphisms (SNPs) afford the advantages of a quicker, less expensive, and less demanding option compared to other methods for sequence analysis. The evaluation of large populations of patients for multiple SNPs in a high-throughput manner is the next phase in individualized medicine. RESULTS: We demonstrated that Tm profiles can...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.