Article
High-resolution melting analysis (HRMA): more than just sequence variant screening.
Human mutation - 1 Jun 2009
Vossen Rolf H A M, Aten Emmelien, Roos Anja, den Dunnen Johan T
Abstract excerpt
Transition of the double-stranded DNA molecule to its two single strands, DNA denaturation or melting, has been used for many years to study DNA structure and composition. Recent technological advances have improved the potential of this technology, especially to detect variants in the DNA sequence. Sensitivity and specificity were increased significantly by the development of so-called saturating DNA dyes and by...
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