Article
Rapid and sensitive detection of BRCA1/2 mutations in a diagnostic setting: comparison of two high-resolution melting platforms.
Clinical chemistry - 1 Jun 2008
De Leeneer Kim, Coene Ilse, Poppe Bruce, De Paepe Anne, Claes Kathleen
Abstract excerpt
BACKGROUND: High-resolution melting is an emerging technique for detection of nucleic acid sequence variations. Developments in instrumentation and saturating intercalating dyes have made accurate high-resolution melting analysis possible and created opportunities to use this technology in diagnostic settings. We evaluated 2 high-resolution melting instruments for screening BRCA1 and BRCA2 mutations. METHODS: To...
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