RAS mutations in pediatric leukemias with MLL gene rearrangements.

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Article

RAS mutations in pediatric leukemias with MLL gene rearrangements.

Genes, chromosomes & cancer - 1 Mar 1998

Mahgoub N, Parker R I, Hosler M R, Close P, Winick N J, Masterson M, Shannon K M, Felix C A

Abstract excerpt

Translocations of the MLL gene at chromosome band 11q23 are the most common cytogenetic alterations in de novo leukemia in infants and in leukemia related to chemotherapy with DNA topoisomerase II inhibitors. Experiments on knock-in mice suggest that additional mutational events may by required f...

Topics

Adolescent
Child
Child, Preschool
DNA-Binding Proteins
Female
Genes, ras
Histone-Lysine N-Methyltransferase
Humans
Leukemia
Leukemia, Myeloid, Acute
Male
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myelodysplastic Syndromes

Myeloid-Lymphoid Leukemia Protein

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Proto-Oncogenes

Transcription Factors

Translocation, Genetic

Source

Open in PubMed

Identifiers

PMID: 9523205

Genes

KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9523205-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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