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Article

Genetic variation in the upstream region of ERG and prostate cancer.

Cancer causes & control : CCC - 1 Sept 2009

Lindström Sara, Adami Hans-Olov, Bälter Katarina, Xu Jianfeng, Zheng S Lilly, Sun Jielin, Stattin Pär, Grönberg Henrik, Wiklund Fredrik

Abstract excerpt

OBJECTIVE: A considerable fraction of prostate cancers harbor a gene fusion between the androgen-regulated TMPRSS2 and ERG, one of the most frequently over-expressed proto-oncogenes in prostate cancer. Here, we investigated if inherited genetic variation upstream of ERG alters prostate cancer ris...

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Source

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Identifiers

PMID: 19205910
DOI: 10.1007/s10552-009-9305-3
PMCID: PMC3755494

Genes

ERG
CAPS
TMPRSS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19205910-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Genetic variation in the upstream region of ERG and prostate cancer.PMID 19205910Read ↗

Association of Prostate Cancer Risk Variants with TMPRSS2:ERG Status: Evidence for Distinct Molecular Subtypes.Semantic proximity Read ↗

Etiology of prostate cancer with the TMPRSS2:ERG fusion: A systematic review of risk factors.Semantic proximity Read ↗

Androgen receptor CAG repeat polymorphism and risk of TMPRSS2:ERG-positive prostate cancer.Semantic proximity Read ↗

ERG rearrangement is specific to prostate cancer and does not occur in any other common tumor.Semantic proximity Read ↗

Systematic analysis reveals molecular characteristics of ERG-negative prostate cancer.Semantic proximity Read ↗

Significance of the TMPRSS2:ERG gene fusion in prostate cancer.Semantic proximity Read ↗

TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohortSemantic proximity Read ↗

TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer.Semantic proximity Read ↗

Duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancerSemantic proximity Read ↗

5' UTR control of native ERG and of Tmprss2:ERG variants activity in prostate cancer.Semantic proximity Read ↗

Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer.Semantic proximity Read ↗

Exploration of oncogenic cooperation between germline variation and somatic mutation in prostate cancer progressionSemantic proximity Read ↗

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