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Article

Genetic variation in the upstream region of ERG and prostate cancer.

Cancer causes & control : CCC - 1 Sept 2009

Lindström Sara, Adami Hans-Olov, Bälter Katarina, Xu Jianfeng, Zheng S Lilly, Sun Jielin, Stattin Pär, Grönberg Henrik, Wiklund Fredrik

Abstract excerpt

OBJECTIVE: A considerable fraction of prostate cancers harbor a gene fusion between the androgen-regulated TMPRSS2 and ERG, one of the most frequently over-expressed proto-oncogenes in prostate cancer. Here, we investigated if inherited genetic variation upstream of ERG alters prostate cancer risk and survival. METHODS: We genotyped 21 haplotype tagging SNPs (htSNPs) covering 123 kb of 5'UTR DNA including exon 3...

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Source

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Identifiers

PMID: 19205910
DOI: 10.1007/s10552-009-9305-3
PMCID: PMC3755494

Genes

ERG
CAPS
TMPRSS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic variation in the upstream region of ERG and prostate cancer.PMID 19205910Read ↗

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ERG rearrangement is specific to prostate cancer and does not occur in any other common tumor.Semantic proximity Read ↗

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TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer.Semantic proximity Read ↗

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