Article
Association of Prostate Cancer Risk Variants with TMPRSS2:ERG Status: Evidence for Distinct Molecular Subtypes.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2016
Penney Kathryn L, Pettersson Andreas, Shui Irene M, Graff Rebecca E, Kraft Peter, Lis Rosina T, Sesso Howard D, Loda Massimo, Mucci Lorelei A
Abstract excerpt
BACKGROUND: Numerous genetic variants have been confirmed as prostate cancer risk factors. These variants may confer susceptibility to the development of specific molecular alterations during tumor initiation and progression. The TMPRSS2:ERG gene fusion occurs in roughly 50% of prostate cancers. Genetic risk variants may influence the development of this fusion. We sought to determine whether prostate cancer risk...
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