Article
Androgen receptor CAG repeat polymorphism and risk of TMPRSS2:ERG-positive prostate cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2014
Yoo Sun, Pettersson Andreas, Jordahl Kristina M, Lis Rosina T, Lindstrom Sara, Meisner Allison, Nuttall Elizabeth J, Stack Edward C, Stampfer Meir J, Kraft Peter, Brown Myles, Loda Massimo, Giovannucci Edward L, Kantoff Philip W, Mucci Lorelei A
Abstract excerpt
BACKGROUND: The androgen receptor (AR) is an essential gene in prostate cancer pathogenesis and progression. Genetic variation in AR exists, including a polymorphic CAG repeat sequence that is inversely associated with transcriptional activity. Experimental data suggest that heightened AR activity facilitates formation of TMPRSS2:ERG, a gene fusion present in approximately 50% of tumors of patients with prostate...
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