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Article

Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer.

BMC cancer - 11 Aug 2008

FitzGerald Liesel M, Agalliu Ilir, Johnson Karynn, Miller Melinda A, Kwon Erika M, Hurtado-Coll Antonio, Fazli Ladan, Rajput Ashish B, Gleave Martin E, Cox Michael E, Ostrander Elaine A, Stanford Janet L, Huntsman David G

Abstract excerpt

BACKGROUND: The presence of the TMPRSS2-ERG fusion gene in prostate tumors has recently been associated with an aggressive phenotype, as well as recurrence and death from prostate cancer. These associations suggest the hypothesis that the gene fusion may be used as a prognostic indicator for prostate cancer. METHODS: In this study, fluorescent in situ hybridization (FISH) assays were used to assess TMPRSS2-ERG...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

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Share to Oncogene Proteins, Fusion

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Source

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Identifiers

PMID: 18694509
DOI: 10.1186/1471-2407-8-230
PMCID: PMC2519091

Genes

TMPRSS2
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of TMPRSS2-ERG gene fusion with clinical characteristics and outcomes: results from a population-based study of prostate cancer.PMID 18694509Read ↗

Association of Prostate Cancer Risk Variants with TMPRSS2:ERG Status: Evidence for Distinct Molecular Subtypes.Semantic proximity Read ↗

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Etiology of prostate cancer with the TMPRSS2:ERG fusion: A systematic review of risk factors.Semantic proximity Read ↗

TMPRSS2-ERG fusion is frequently observed in gleason pattern 3 prostate cancer in a Canadian cohortSemantic proximity Read ↗

TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer.Semantic proximity Read ↗

[TMPRSS2-ETS gene fusion in prostate cancer].Semantic proximity Read ↗

Genome-wide linkage analysis of TMPRSS2-ERG fusion in familial prostate cancer.Semantic proximity Read ↗

Expression of the TMPRSS2:ERG fusion gene predicts cancer recurrence after surgery for localised prostate cancerSemantic proximity Read ↗

Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancerSemantic proximity Read ↗

Epigenomic profiling of prostate cancer identifies differentially methylated genes in TMPRSS2:ERG fusion-positive versus fusion-negative tumorsSemantic proximity Read ↗

Systematic analysis reveals molecular characteristics of ERG-negative prostate cancer.Semantic proximity Read ↗

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