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Article

Systematic analysis reveals molecular characteristics of ERG-negative prostate cancer.

Scientific reports - 27 Aug 2018

Xiao Qingyu, Sun Yidi, Dobi Albert, Srivastava Shiv, Wang Wendy, Srivastava Sudhir, Ji Yuan, Hou Jun, Zhao Guo-Ping, Li Yixue, Li Hong

Abstract excerpt

The TMPRSS2:ERG gene fusion is the most prevalent early driver gene activation in prostate cancers of European ancestry, while the fusion frequency is much lower in Africans and Asians. The genomic characteristics and mechanisms for patients lacking ERG fusion are still unclear. In this study, we systematically compared the characteristics of gene fusions, somatic mutations, copy number alterations and gene...

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Share to DNA Methylation
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Neoplasm Grading

Share to Neoplasm Staging

Share to Oncogene Proteins, Fusion

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Share to Transcriptional Regulator ERG

Source

Open in PubMed Open full text

Identifiers

PMID: 30150711
DOI: 10.1038/s41598-018-30325-9
PMCID: PMC6110738

Genes

ERG
TMPRSS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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