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Article

Significance of the TMPRSS2:ERG gene fusion in prostate cancer.

Molecular medicine reports - 1 Oct 2017

Wang Zhu, Wang Yuliang, Zhang Jianwen, Hu Qiyi, Zhi Fan, Zhang Shengping, Mao Dengqi, Zhang Ying, Liang Hui

Abstract excerpt

The transmembrane protease serine 2:v‑ets erythroblastosis virus E26 oncogene homolog (TMPRSS2:ERG) gene fusion is common in prostate cancer, while its functional role is not fully understood. The present study aimed to investigate the significance of the TMPRSS2:ERG gene fusion in human prostate cancers using bioinformatics tools. Comprehensive alteration analysis of TMPRSS2 and ERG in 148 different human cancer...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 28849022
DOI: 10.3892/mmr.2017.7281
PMCID: PMC5647090

Genes

ERG
TMPRSS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Significance of the TMPRSS2:ERG gene fusion in prostate cancer.PMID 28849022Read ↗

TMPRSS2-ERG Fusion Gene Expression in Prostate Tumor Cells and Its Clinical and Biological Significance in Prostate Cancer ProgressionSemantic proximity Read ↗

ETS fusion genes in prostate cancerSemantic proximity Read ↗

Systematic analysis reveals molecular characteristics of ERG-negative prostate cancer.Semantic proximity Read ↗

The Expression of Proto-Oncogene ETS-Related Gene (ERG) Plays a Central Role in the Oncogenic Mechanism Involved in the Development and Progression of Prostate CancerSemantic proximity Read ↗

Etiology of prostate cancer with the TMPRSS2:ERG fusion: A systematic review of risk factors.Semantic proximity Read ↗

Comprehensive analysis of oncogenic signatures and consequent repurposed drugs in TMPRSS2:ERG fusion‐positive prostate cancerSemantic proximity Read ↗

TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer.Semantic proximity Read ↗

[TMPRSS2-ETS gene fusion in prostate cancer].Semantic proximity Read ↗

The Discovery of Common Recurrent Transmembrane Protease Serine 2 (TMPRSS2)-Erythroblastosis Virus E26 Transforming Sequence (ETS) Gene Fusions in Prostate CancerSemantic proximity Read ↗

Clinical Applications of Novel ERG Immunohistochemistry in Prostate Cancer Diagnosis and ManagementSemantic proximity Read ↗

Association of Prostate Cancer Risk Variants with TMPRSS2:ERG Status: Evidence for Distinct Molecular Subtypes.Semantic proximity Read ↗

ERG rearrangement is specific to prostate cancer and does not occur in any other common tumor.Semantic proximity Read ↗

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