Article
TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer.
Cancer research - 1 Sept 2006
Perner Sven, Demichelis Francesca, Beroukhim Rameen, Schmidt Folke H, Mosquera Juan-Miguel, Setlur Sunita, Tchinda Joelle, Tomlins Scott A, Hofer Matthias D, Pienta Kenneth G, Kuefer Rainer, Vessella Robert, Sun Xiao-Wei, Meyerson Matthew, Lee Charles, Sellers William R, Chinnaiyan Arul M, Rubin Mark A
Abstract excerpt
Prostate cancer is a common and clinically heterogeneous disease with marked variability in progression. The recent identification of gene fusions of the 5'-untranslated region of TMPRSS2 (21q22.3) with the ETS transcription factor family members, either ERG (21q22.2), ETV1 (7p21.2), or ETV4 (17q21), suggests a mechanism for overexpression of the ETS genes in the majority of prostate cancers. In the current study...
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