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Article

p53 represses c-Myc through induction of the tumor suppressor <i>miR-145</i>

7 Feb 2009

Abstract excerpt

The tumor suppressor p53 negatively regulates a number of genes, including the proto-oncogene c-Myc, in addition to activating many other genes. One mechanism of the p53-mediated c-Myc repression may involve transcriptional regulation. However, it is not clear whether microRNAs (miRNAs) play a role in the p53-mediated posttranscriptional regulation of c-Myc. In this study, we show that a putative tumor...

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PMID: 19202062
DOI: 10.1073/pnas.0808042106

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