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Tumorigenicity of cancer stem-like cells derived from hepatocarcinoma is regulated by microRNA-145

28 Feb 2012

Abstract excerpt

microRNAs are implicated in cancer initiation and progression by their ability to affect the expression of genes and proteins that regulate cell proliferation and death. Recent studies found that the stem cell-related genes Sox2, Oct4 and Klf4 are among the target genes regulated by microRNA-145 (miR-145), suggesting that miR-145 possibly plays a role in the maintenance of cancer stem cells. Therefore, it is...

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PMID: 22378186
DOI: 10.3892/or.2012.1701

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