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Article

MicroRNA-145 is regulated by DNA methylation and p53 gene mutation in prostate cancer.

Carcinogenesis - 1 May 2011

Suh Seong O, Chen Yi, Zaman Mohd Saif, Hirata Hiroshi, Yamamura Soichiro, Shahryari Varahram, Liu Jan, Tabatabai Z Laura, Kakar Sanjay, Deng Guoren, Tanaka Yuichiro, Dahiya Rajvir

Abstract excerpt

MiR-145 is downregulated in various cancers including prostate cancer. However, the underlying mechanisms of miR-145 downregulation are not fully understood. Here, we reported that miR-145 was silenced through DNA hypermethylation and p53 mutation status in laser capture microdissected (LCM) prostate cancer and matched adjacent normal tissues. In 22 of 27 (81%) prostate tissues, miR-145 was significantly...

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Identifiers

PMID: 21349819
DOI: 10.1093/carcin/bgr036
PMCID: PMC3086703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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