Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

microRNA-145 suppresses lung adenocarcinoma-initiating cell proliferation by targeting OCT4

7 Apr 2011

Abstract excerpt

Recent studies demonstrated that microRNA-145 is downregulated in human cancer cells and may function as a tumor suppressor. However, its role in lung cancer tumorigenesis remains unclear. Here, we demonstrated that upregulation of miR-145 reduced the proliferation and invasion as well as the ratio of CD133-positive initiating cells and the tumorosphere growth capacity of the human lung adenocarcinoma A549 cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to MicroRNA in disease regulation
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21479367
DOI: 10.3892/or.2011.1252

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

microRNA-145 suppresses lung adenocarcinoma-initiating cell proliferation by targeting OCT4PMID 21479367Read ↗

MiR-145 regulates cancer stem-like properties and epithelial-to-mesenchymal transition in lung adenocarcinoma-initiating cellsSemantic proximity Read ↗

MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1.Semantic proximity Read ↗

MiRNA-145 suppresses lung adenocarcinoma cell invasion and migration by targeting N-cadherinSemantic proximity Read ↗

Tumorigenicity of cancer stem-like cells derived from hepatocarcinoma is regulated by microRNA-145Semantic proximity Read ↗

Regulatory mechanisms of miR-145 expression and the importance of its function in cancer metastasisSemantic proximity Read ↗

Downregulation of microRNA-145 promotes epithelial–mesenchymal transition via regulating Snail in osteosarcomaSemantic proximity Read ↗

MiR-145 in cancer therapy resistance and sensitivity: A comprehensive review.Semantic proximity Read ↗

MicroRNA-145 overexpression inhibits neuroblastoma tumorigenesis in vitro and in vivoSemantic proximity Read ↗

Restoration of tumour suppressor hsa-miR-145 inhibits cancer cell growth in lung adenocarcinoma patients with epidermal growth factor receptor mutation.Semantic proximity Read ↗

MiR‐145 inhibits human colorectal cancer cell migration and invasion via PAK4‐dependent pathwaySemantic proximity Read ↗

Expression of micro-RNA-145 is regulated by a highly conserved genomic sequence 3' to the pre-miR.Semantic proximity Read ↗

Identification of Tumor Suppressive miR-144-5p Targets: FAM111B Expression Accelerates the Malignant Phenotypes of Lung Adenocarcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.