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Article

Regulatory mechanisms of miR-145 expression and the importance of its function in cancer metastasis

2 Nov 2018

Abstract excerpt

MicroRNAs are post-transcriptional mediators of gene expression and regulation, which play influential roles in tumorigenesis and cancer metastasis. The expression of tumor suppressor miR-145 is reduced in various cancer cell lines, containing both solid tumors and blood malignancies. However, the responsible mechanisms of its down-regulation are a complicated network. miR-145 is potentially able to inhbit tumor...

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PMID: 30396077
DOI: 10.1016/j.biopha.2018.10.037

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