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Article

Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival.

Cell stem cell - 6 Feb 2009

Souroullas George P, Salmon Jessica M, Sablitzky Fred, Curtis David J, Goodell Margaret A

Abstract excerpt

Scl and Lyl1 encode two related basic-helix-loop-helix transcription factors implicated in T cell acute lymphoblastic leukemia. Previous studies showed that Scl is essential for embryonic and adult erythropoiesis, while Lyl1 is important for B cell development. Single-knockout mice have not revealed an essential function for Scl or Lyl1 in adult hematopoietic stem cells (HSCs). To determine if maintenance of HSCs...

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Identifiers

PMID: 19200805
DOI: 10.1016/j.stem.2009.01.001
PMCID: PMC2672304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival.PMID 19200805Read ↗

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