Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Shared roles for Scl and Lyl1 in murine platelet production and function

12 Jul 2019

Abstract excerpt

Abstract The stem cell leukemia (Scl or Tal1) protein forms part of a multimeric transcription factor complex required for normal megakaryopoiesis. However, unlike other members of this complex such as Gata1, Fli1, and Runx1, mutations of Scl have not been observed as a cause of inherited thrombocytopenia. We postulated that functional redundancy with its closely related family member, lymphoblastic leukemia 1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to Platelet Disorders and Treatments
Share to Renal Diseases and Glomerulopathies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31300405
DOI: 10.1182/blood.2019896175

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Shared roles for Scl and Lyl1 in murine platelet production and functionPMID 31300405Read ↗

The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.Semantic proximity Read ↗

Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival.Semantic proximity Read ↗

Inherited platelet dysfunction and hematopoietic transcription factor mutations.Semantic proximity Read ↗

Hematopoietic transcription factor mutations: important players in inherited platelet defects.Semantic proximity Read ↗

Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferationSemantic proximity Read ↗

FLI1 monoallelic expression combined with its hemizygous loss underlies Paris-Trousseau/Jacobsen thrombopeniaSemantic proximity Read ↗

Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage.Semantic proximity Read ↗

The Gp1ba-Cre transgenic mouse: a new model to delineate platelet and leukocyte functionsSemantic proximity Read ↗

Rescue of the lethal scl(-/-) phenotype by the human SCL locus.Semantic proximity Read ↗

Distinct Functions for Different scl Isoforms in Zebrafish Primitive and Definitive HematopoiesisSemantic proximity Read ↗

The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse.Semantic proximity Read ↗

The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.