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Article

The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse.

The EMBO journal - 15 Aug 1996

Robb L, Elwood N J, Elefanty A G, Köntgen F, Li R, Barnett L D, Begley C G

Abstract excerpt

Homozygosity for a null mutation in the scl gene causes mid-gestational embryonic lethality in the mouse due to failure of development of primitive hematopoiesis. Whilst this observation established the role of the scl gene product in primitive hematopoiesis, the death of the scl null embryos precluded analysis of the role of scl in later hematopoietic development. To address this question, we created embryonic...

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Identifiers

PMID: 8861941
PMCID: PMC452135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse.PMID 8861941Read ↗

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Non-cell autonomous requirement for the bloodless gene in primitive hematopoiesis of zebrafish.Semantic proximity Read ↗

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