Article
The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse.
The EMBO journal - 15 Aug 1996
Robb L, Elwood N J, Elefanty A G, Köntgen F, Li R, Barnett L D, Begley C G
Abstract excerpt
Homozygosity for a null mutation in the scl gene causes mid-gestational embryonic lethality in the mouse due to failure of development of primitive hematopoiesis. Whilst this observation established the role of the scl gene product in primitive hematopoiesis, the death of the scl null embryos pre...
Topics
- Animals
- Basic Helix-Loop-Helix Transcription Factors
- Bone Marrow Cells
- Cell Lineage
- Chimera
- DNA-Binding Proteins
- Female
- Gene Targeting
- Genes, Lethal
- Genotype
- Hematopoiesis
- Liver
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Organ Specificity
- Proto-Oncogene Proteins
- Stem Cells