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Article

Promoter knock-in mutations reveal a role of Mcl-1 in thymocyte-positive selection and tissue or cell lineage-specific regulation of Mcl-1 expression.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2009

Yang Chia-Yu, Lin Nai-Hui, Lee Jan-Mou, Huang Ching-Yu, Min Hsiang-Ju, Yen Jeffrey Jong-Young, Liao Nan-Shih, Yang-Yen Hsin-Fang

Abstract excerpt

We previously demonstrated that IL-3 stimulates transcription of the antiapoptotic gene mcl-1 via two promoter elements designated as the SIE and CRE-2 sites. To further study the functional role of these two DNA elements, mutant mice with targeted mutations of both SIE and CRE-2 sites (SC mutants) were generated. Homozygous SC mutants manifested a markedly reduced level of Mcl-1 in thymus but not in other major...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myeloid Cell Leukemia Sequence 1 Protein

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Share to Proto-Oncogene Proteins c-bcl-2

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Source

Identifiers

PMID: 19234191
DOI: 10.4049/jimmunol.0803550

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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