Integrated genome-wide DNA copy number and expression analysis identifies distinct mechanisms of primary chemoresistance in ovarian carcinomas.

doi:10.1158/1078-0432.CCR-08-1564

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Integrated genome-wide DNA copy number and expression analysis identifies distinct mechanisms of primary chemoresistance in ovarian carcinomas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Feb 2009

Etemadmoghadam Dariush, deFazio Anna, Beroukhim Rameen, Mermel Craig, George Joshy, Getz Gad, Tothill Richard, Okamoto Aikou, Raeder Maria B, Harnett Paul, Lade Stephen, Akslen Lars A, Tinker Anna V, Locandro Bianca, Alsop Kathryn, Chiew Yoke-Eng, Traficante Nadia, Fereday Sian, Johnson Daryl, Fox Stephen, Sellers William, Urashima Mitsuyoshi, Salvesen Helga B, Meyerson Matthew, Bowtell David

Abstract excerpt

PURPOSE: A significant number of women with serous ovarian cancer are intrinsically refractory to platinum-based treatment. We analyzed somatic DNA copy number variation and gene expression data to identify key mechanisms associated with primary resistance in advanced-stage serous cancers. EXPERIMENTAL DESIGN: Genome-wide copy number variation was measured in 118 ovarian tumors using high-resolution...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin E

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

Share to Gene Dosage

Share to Histone Acetyltransferases

Share to Ki-67 Antigen

Share to Oncogene Proteins

Share to Ovarian Neoplasms

Share to Trans-Activators

Source

Open in PubMed Open full text

Identifiers

PMID: 19193619
DOI: 10.1158/1078-0432.CCR-08-1564
PMCID: PMC2670486

Genes

CCNE1
NCOA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrated genome-wide DNA copy number and expression analysis identifies distinct mechanisms of primary chemoresistance in ovarian carcinomas.PMID 19193619Read ↗

Genome Wide DNA Copy Number Analysis of Serous Type Ovarian Carcinomas Identifies Genetic Markers Predictive of Clinical OutcomeSemantic proximity Read ↗

The copy number and mutational landscape of recurrent ovarian high-grade serous carcinoma.Semantic proximity Read ↗

Expression profiling of primary and metastatic ovarian tumors reveals differences indicative of aggressive disease.Semantic proximity Read ↗

Gene amplification <i>CCNE1</i> is related to poor survival and potential therapeutic target in ovarian cancerSemantic proximity Read ↗

The genomic landscape of recurrent ovarian high grade serous carcinoma: the BriTROC-1 studySemantic proximity Read ↗

Platinum resistance induces diverse evolutionary trajectories in high grade serous ovarian cancerSemantic proximity Read ↗

Analysis of Chemotherapeutic Response in Ovarian Cancers Using Publicly Available High-Throughput DataSemantic proximity Read ↗

Copy number signatures and mutational processes in ovarian carcinoma.Semantic proximity Read ↗

Comprehensive characterization of genomic features and clinical outcomes following targeted therapy and secondary cytoreductive surgery in OCCC: a single center experience.Semantic proximity Read ↗

Clonal somatic copy number altered driver events inform drug sensitivity in high-grade serous ovarian cancerSemantic proximity Read ↗

Comprehensive molecular characterization identifies therapeutic vulnerabilities in ovarian clear cell carcinoma.Semantic proximity Read ↗

Frequent CCNE1 amplification in endometrial intraepithelial carcinoma and uterine serous carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.