The copy number and mutational landscape of recurrent ovarian high-grade serous carcinoma.

doi:10.1038/s41467-023-39867-7

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Article

The copy number and mutational landscape of recurrent ovarian high-grade serous carcinoma.

Nature communications - 20 Jul 2023

Smith Philip, Bradley Thomas, Gavarró Lena Morrill, Goranova Teodora, Ennis Darren P, Mirza Hasan B, De Silva Dilrini, Piskorz Anna M, Sauer Carolin M, Al-Khalidi Sarwah, Funingana Ionut-Gabriel, Reinius Marika A V, Giannone Gaia, Lewsley Liz-Anne, Stobo Jamie, McQueen John, Bryson Gareth, Eldridge Matthew, Macintyre Geoff, Markowetz Florian, Brenton James D, McNeish Iain A

Abstract excerpt

The drivers of recurrence and resistance in ovarian high grade serous carcinoma remain unclear. We investigate the acquisition of resistance by collecting tumour biopsies from a cohort of 276 women with relapsed ovarian high grade serous carcinoma in the BriTROC-1 study. Panel sequencing shows close concordance between diagnosis and relapse, with only four discordant cases. There is also very strong concordance...

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Identifiers

PMID: 37474499
DOI: 10.1038/s41467-023-39867-7
PMCID: PMC10359414

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Source receipt: pubmed, retrieved 7 Sept 2026.

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