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Article

Comprehensive molecular characterization identifies therapeutic vulnerabilities in ovarian clear cell carcinoma.

Genome medicine - 6 May 2026

Wu Yong, Guo Xinyi, Wang Tiantian, Zhao Tianyi, Chen Siyu, Su Ying, Li Qin, Zhu Jun, Xia Lingfang, Ju Xingzhu, Wu Xiaohua, Huang Shenglin, Hu Zhixiang, Chen Xiaojun

Abstract excerpt

BACKGROUND: Ovarian clear cell carcinoma (OCCC) is a rare aggressive, and chemo-resistant subtype of epithelial ovarian cancer. Current limitations in precisely characterizing its molecular features have resulted in restricted availability of clinical targeted therapies and significant therapeutic challenges. METHODS: To address this unmet need, we conducted an integrative multi-omics study of 82 OCCC cases,...

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Topics

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Share to Adenocarcinoma, Clear Cell
Share to DNA Copy Number Variations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Exome Sequencing

Share to Gene Expression Regulation, Neoplastic

Share to Mutation

Share to Ovarian Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 42087217
DOI: 10.1186/s13073-026-01663-5
PMCID: PMC13312614

Genes

ERBB2
ARID1A
EP300
FGFR2
FOXA2
RPAP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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