Article
A pooling-based genome-wide association study implicates the p73 gene in chronic rhinosinusitis.
Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale - 1 Apr 2010
Tournas Athanasios, Mfuna Leandra, Bossé Yohan, Filali-Mouhim Abdelali, Grenier Jean-Paul, Desrosiers Martin
Abstract excerpt
BACKGROUND: p73 is a gene that may confer a genetic susceptibility to the development of chronic rhinosinusitis. OBJECTIVE: To verify an association between p73 and chronic rhinosinusitis, identified in a pooling-based genome-wide association study in a human population. METHODS: Prospective recruitment of 206 patients and 196 postal code-matched controls. DNA extraction, followed by pooling, high-density single...
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