Article
The efficacy of detecting variants with small effects on the Affymetrix 6.0 platform using pooled DNA.
Human genetics - 1 Nov 2011
Chiang Charleston W K, Gajdos Zofia K Z, Korn Joshua M, Butler Johannah L, Hackett Rachel, Guiducci Candace, Nguyen Thutrang T, Wilks Rainford, Forrester Terrence, Henderson Katherine D, Le Marchand Loic, Henderson Brian E, Haiman Christopher A, Cooper Richard S, Lyon Helen N, Zhu Xiaofeng, McKenzie Colin A, Palmert Mark R, Hirschhorn Joel N
Abstract excerpt
Genome-wide genotyping of a cohort using pools rather than individual samples has long been proposed as a cost-saving alternative for performing genome-wide association (GWA) studies. However, successful disease gene mapping using pooled genotyping has thus far been limited to detecting common variants with large effect sizes, which tend not to exist for many complex common diseases or traits. Therefore, for DNA...
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