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Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells.

DNA repair - 1 Apr 2021

Suzuki Tetsuya, Sassa Akira, Grúz Petr, Gupta Ramesh C, Johnson Francis, Adachi Noritaka, Nohmi Takehiko

Abstract excerpt

DNA polymerase ζ (Pol ζ) is a specialized Pol that is involved in translesion DNA synthesis (TLS), in particular, in the extension of primer DNA after bypassing DNA lesions. Previously, we established human cells that express a variant form of Pol ζ with an amino acid change of leucine 2618 to methionine (L2618M) in the catalytic subunit REV3L (DNA Repair, 45, 34-43, 2016). This amino acid change made the cells...

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PMID: 33607474
DOI: 10.1016/j.dnarep.2021.103052

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