Biased distribution of action-at-a-distance mutations by 8-oxo-7,8-dihydroguanine.

doi:10.1016/j.mrfmmm.2022.111794

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Biased distribution of action-at-a-distance mutations by 8-oxo-7,8-dihydroguanine.

Mutation research - 1 Jan 2000

Fukushima Ruriko, Suzuki Tetsuya, Komatsu Yasuo, Kamiya Hiroyuki

Abstract excerpt

8-Oxo-7,8-dihydroguanine (8-hydroxyguanine, G°) is a major oxidized base that is considered to play pivotal roles in the pathogenesis of various diseases, including cancer. G° induces G:C → T:A transversions at the damage site and untargeted (action-at-a-distance) mutations of G bases at 5'-GpA sequences. In this study, we examined the distribution of the action-at-a-distance mutations and the effects of the...

Topics

Humans
Mutation
Guanine
Plasmids
Mutagenesis
Genetic Vectors

Source

Open in PubMed

Identifiers

PMID: 36027647
DOI: 10.1016/j.mrfmmm.2022.111794

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics