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Article

Untargeted Mutation Triggered by Ribonucleoside Embedded in DNA.

International journal of molecular sciences - 22 Dec 2024

Suzuki Tetsuya, Yasui Kiyoharu, Komatsu Yasuo, Kamiya Hiroyuki

Abstract excerpt

DNA polymerases frequently misincorporate ribonucleoside 5'-triphosphates into nascent DNA strands. This study examined the effects of an incorporated ribonucleoside on untargeted mutations in human cells. Riboguanosine (rG) was introduced into the downstream region of the supF gene to preferentially detect the untargeted mutations. The plasmid containing rG was transfected into U2OS cells and the replicated DNA...

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PMID: 39769470
DOI: 10.3390/ijms252413708

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