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Mutagenicity of 5-hydroxycytosine in human cells.

Mutagenesis - 24 Apr 2026

Suzuki Tetsuya, Hirota Ann, Iwai Shigenori, Kamiya Hiroyuki

Abstract excerpt

Base damage in DNA constitutes a major source of mutations, and consequently leads to cancers. In human cells, 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) induces targeted G → T transversions, and untargeted base substitution mutations at positions distant from the damaged site (action-at-a-distance mutations). OGG1 is a base excision repair enzyme and suppresses the former mutations, but is involved in the...

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Identifiers

PMID: 41626744
DOI: 10.1093/mutage/geag004

Genes

OGG1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Mutagenicity of 5-hydroxycytosine in human cells.PMID 41626744Read ↗

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