Effects of differential genotyping error rate on the type I error probability of case-control studies.

doi:10.1159/000092553

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Article

Effects of differential genotyping error rate on the type I error probability of case-control studies.

Human heredity - 1 Jan 2006

Moskvina Valentina, Craddock Nick, Holmans Peter, Owen Michael J, O'Donovan Michael C

Abstract excerpt

OBJECTIVES: It is well known that genotyping error adversely affects the power of genetic case-control association studies but there is little research on its effects on type I error, and none that has addressed possible differences in genotype error rates between cases and controls. METHODS: We used simulations to examine the influence of genotyping error on the type I error probability given by case-control...

Topics

Alleles
Case-Control Studies
Computer Simulation
Data Interpretation, Statistical
Gene Frequency
Genotype
Haplotypes
Humans
Linkage Disequilibrium
Models, Genetic
Models, Statistical
Probability
Reproducibility of Results

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PMID: 16612103
DOI: 10.1159/000092553

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