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Article

OptGraft: A computational procedure for transferring a binding site onto an existing protein scaffold.

Protein science : a publication of the Protein Society - 1 Jan 2009

Fazelinia Hossein, Cirino Patrick C, Maranas Costas D

Abstract excerpt

One of the many challenging tasks of protein design is the introduction of a completely new function into an existing protein scaffold. In this study, we introduce a new computational procedure OptGraft for placing a novel binding pocket onto a protein structure so as its geometry is minimally perturbed. This is accomplished by introducing a two-level procedure where we first identify where are the most...

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Identifiers

PMID: 19177362
DOI: 10.1002/pro.2
PMCID: PMC2708043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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