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Article

Asymmetric functions of a binuclear metal center within the transport pathway of a human zinc transporter ZIP4.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2020

Zhang Tuo, Sui Dexin, Zhang Chi, Cole Logan, Hu Jian

Abstract excerpt

Metal clusters are exploited by numerous metalloenzymes for catalysis, but it is not common to utilize a metal cluster for substrate transport across membrane. The recent crystal structure of a prototypic Zrt-/Irt-like protein (ZIP) metal transporter from Bordetella bronchiseptica (BbZIP) revealed an unprecedented binuclear metal center (BMC) within the transport pathway. Here, through a combination of...

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Identifiers

PMID: 31914589
DOI: 10.1096/fj.201902043R
PMCID: PMC6956730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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